Name

Personal

PhD in Biology (Institute of Translational Immunology, University Medical Centre, Mainz, Germany)

Field of Specialization: Cancer Immunotherapy

Postal Address: House #299, street #11, sector E5 Hayatabad phase 7, Peshawar

Email : misbahmmg@gmail.com

Cell No. 03149451944

Date of Birth: 27.05.1985

Place of Birth: Kohat, Pakistan

Experience

Working as a lecturer under BPS-18 at Department of Microbiology, Shaheed Benazir Bhutto Women University,Peshawar since 2013.

Qualification

2015-2019   PhD, Institute of Translational Immunology, University Medical Centre, Mainz, Germany

2009-2011    Masters of Science (MS) in Microbiology & Molecular Genetics, Punjab University, Pakistan

2004-2008    Bachelors of Microbiology, Kohat University of Science & technology, Pakistan

2001-2003     Higher Secondary School Certificate, FBISE, Islamabad, Pakistan

1999-2001     Secondary School Certificate, FBISE, Islamabad, Pakistan

Honor and Awards

1. Young investigator travel grant (650€)  to present scientific data in EASL International Liver Congress 2019, Vienna, Austria
2. Young investigator free registration grant to present scientific data in EASL International Liver Congress 2018, Paris, France
3. Young investigator travel grant (600€)  to present scientific data in HCC summit 2018, Geneva, Switzerland
4. Got a travel grant for oral presentation in Visceral medicine conference 2017 by German Society of Gastroenterology, Digestive and metabolic diseases (DGVS)
5. Awarded by young Investigator bursary (600€) for poster presentation in EASL International Liver Congress 2017, Amsterdam, Netherland
6. “Distinguished Poster Award” in American Association for Liver diseases (AASLD 2016)
7. Awarded by Faculty Development Studies of SBBWUP under HEC for PhD studies in Foreign Countries
8. DPCC Merit Scholarship holder during MS in Punjab during 2010-2011
9. Merit scholarship holder in BS (Hons) Microbiology Kohat University of Science and Technology session 2004-2008

Memberships

The European Association for the Study of Liver

Graduate Students Postdocs Undergraduate Students Honor Students

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Service Activity

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Brief Statement of Research Interest

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Publications

Book/Chapters

Misbah Aslam* and Nazia Jamil. 2015. Plasmid encoded bacteriocin transformation studies in Alcaligenes and Brevundimonas species. The battle against microbial pathogens: basic science, technological advances and educational programs A. Méndez-Vilas (Ed.) Formatex.

Published Journal Articles

1. Yang AT, Kim YO, Yan XZ, Abe H, Aslam M, Park KS, Zhao XY, Jia JD, Klein T, You H, Schuppan D. (2023).Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis. Cellular and Molecular Gastroenterology & Hepatology,15(4):841-867. (IF: 7.1)
2. Geethanjali Pickert, Stefan Wirtz, Johannes Matzner, Muhammad Ashfaq-Khan, Rosario Heck, Sebastian Rosigkeit, Dorothe Thies, Rambabu Surabattula, Jan Wehkamp, Misbah Aslam, Guiwei He, Andreas Weigert, Friedrich Foerster, Luisa Klotz Julia-Stefanie Frick, Christoph Becker, Ernesto Bockamp, Detlef Schuppan*(2020). Wheat consumption aggravates colitis in mice via amylase trypsin inhibitor-mediated dysbiosis. Gastroenterology, 159(1):257-272. (IF: 26.3)
3. Ashfaq-khan M, Aslam M, Qureshi MA, Senkowski M, Weng SY, Strand S, Kim YO, Pickert G, Schattenberg JM& , Schuppan D*.(2019). Dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease. Scientific reports. 9:17463(IF: 3.998)
4. Nadine Leber, Leonard Kaps, Aiting Yang, Misbah Aslam, Maria cristina Giardino, Adrian Klefenz, Niklas Choteschovsky, Sebastian Rosigkeit, Asmaa Mostafa, Lutz Nuhn, Detlef Schuppan* and Rudolf Zentel* (2019). α‐Mannosyl‐Functionalized Cationic Nanohydrogel Particles for Targeted Gene Knockdown in Immunosuppressive Macrophages. Macromolecular Biosciences :e1900162. Epub 2019 Jun 7 (IF: 3.146)
5. Friedrich Foerster, Sebastian Boegel, Rosario Heck, Geetha Pickert, Nina Rüssel, Sebastian Rosigkeit, Matthias Bros, Stephanie Strobl, Leonard Kaps, Misbah Aslam, Mustafa Diken, John Castle, Ugur Sahin, Andrea Tuettenberg, Ernesto Bockamp & Detlef Schuppan*(2018). Enhanced protection of C57BL/6 vs Balb/c mice to melanoma liver metastasis is mediated by NK cells. Oncoimmunology, 7(4), e1409929-12 (IF: 5.869)
6. Nadine Leber, Leonard Kaps, Misbah Aslam,  Jonathan Schupp, Alexander Brose, David Schäffel, Karl Fischer, Mustafa Diken, Dennis Strand, Kaloian Koynov, Andrea Tuettenberg, Lutz Nuhn, Rudolf Zentel and Detlef Schuppan*(2017).  SiRNA-mediated in vivo gene knockdown by acid-degradable cationic nanohydrogel particles. Journal of Controlled Release, 248, 10-23 (IF:7.727)
7. Leonard Kaps, Lutz Nuhn, Misbah Aslam, Alexander Brose, Friedrich Foerster, Sebastian Rosigkeit , Patricia Renz , Rosario Heck , Yong Ook Kim , Ingo Lieberwirth, Detlef Schuppan* and Rudolf Zentel *(2015).In Vivo Gene-Silencing in Fibrotic Liver by siRNA-Loaded Cationic Nanohydrogel Particles. Advanced Healthcare Materials, 4, 2809–2815 (IF:7.367)
8. Misbah Aslam, Muhammad Abubakar, Rehana Anjum, Shamim Saleha, and Qurban Ali. (2009). “Prevalence of Peste des petits Ruminants Virus (PPRV) in Mardan, Hangu and Kohat Districts of Pakistan; Comparative Analysis of PPRV Suspected serum samples using Competitive ELISA (cELISA) and Agar Gel Immunodiffusion (AGID).” Veterinary World, 2(3):89-92. (IF: 1.220)

Manuscripts in preparation

1. “Combined treatment with Rapamycin and Zoledronic acid strongly inhibits growth of murine hepatocellular carcinoma via activation of the immune microenvironment” Aslam M, Ashfaq-Khan M, Qureshi MA, Kaps L, Weng SY, Senkowski M, Nick M, Kim YO, Heck R, Surabattula R, Schuppan, D
2. Qureshi MA, Ashfaq-Khan M, Aslam M, Hessel C, Senkowski M, Gasteiger G, Schuppan D “Innate Lymphoid Cells Type 1 and 2 are Expanded in Early Stages of Hepatocellular Carcinoma in A Novel Murine Model Close to Human Hepatocarcinogenesis”

Oral Presentations

1. “Rapamycin and Zoledronic acid exert a potent antifibrotic effect in murine biliary fibrosis” in August 2018 at Zeitschrift für Gastroenterologie, Munchen, Germany, 56(08):e249-e250(DOI: 10.1055/s-0038-1668783)
2. “Zoledronic Acid promotes tumoricidal immunity and supresses tumour associated macrophages and myeloid derived suppressor cells in murine HCC” in August 2018 at Zeitschrift für Gastroenterologie, Munchen, Germany 56(08):e310-e310( DOI: 10.1055/s-0038-1668942)

Recently Published Abstracts

1. MA Khan, M Aslam, MS Senkowski, D Schuppan. Wheat amylase trypsin inhibitors (ATI) promote liver fibrosis in a murine model of primary sclerosing cholangitis fibrosis. HEPATOLOGY, 2019; 70, 1125A-1125A
2. MA Khan, M Aslam, MS Senkowski, D Schuppan IL-4 receptor alpha knock out mice are protected against fibrotic NASH in a representative model of nonalcoholic steatohepatitis (NASH). HEPATOLOGY,2019; 70, 1293A-1293A
3. MA Khan, M Aslam, MS Senkowski, D Schuppan nutritional wheat amylase trypsin inhibitors (ATI) promote progression of murine primary hepatocellular carcinoma HEPATOLOGY, 2019; 70,1231A-1231A
4. L Kaps, L Nuhn, N Choteschovsky, A Klefenz, M Aslam, D Schuppan. Nanoparticular bisphosphonate to selectively target and repolarize liver macrophages for efficient anti-tumour responses. Zeitschrift für Gastroenterologie, 2019; 57 (09), KV 164
5. Misbah Aslam, Muhammad Ashfaq-Khan, Muhammad Asif Qureshi, Marcel Senkowski, Mirko Nick, Leonard Kaps, Yong Ook Kim, Detlef Schuppan, Synergistic antifibrotic effect of Rapamycin and Zoledronic acid in advanced murine biliary fibrosis. Journal of Hepatology, 2019; 70, E187-E188
6. Misbah Aslam, Muhammad Ashfaq-Khan, Asif Qureshi, Simap Celik, Jan-Timon Werle, Marcel Senkowski, Yong Ook Kim, KAPS Leonard, Detlef Schuppan. Rapamycin promotes tumoricidal immunity in murine HCC by inducing M1-type macrophages and dentritic cells polarization and enhancement of cytotoxic T-cells. Journal of Hepatology, 2019; 70 (1), e595
7.  Muhammad Ashfaq-Khan, Misbah Aslam, Asif Qureshi, Yong Ook Kim, Tim Zimmermann, Detlef Schuppan. Synergistic reduction of cancer proliferation and tumour growth in advanced murine hepatocellular carcinoma vis skewing and activation of innate and adoptive immunity. Journal of Hepatology, 2019; 70 (1), e594-e595
8. Muhammad Ashfaq-Khan, Misbah Aslam, Marcel Senkowski, Detlef Schuppan. IL-4 receptor alpha knock-out mice are protected against fibrotic NASH in a representative mouse model of non-alcoholic steatohepatitis.Journal of Hepatology, 2019; 70 (1), e519
9. Ai Ting Yang, Yong Ook Kim, Misbah Aslam, Maria cristina Giardino, Hiroyuki Abe, Kyoung Sook Park, Muhammad Ashfaq Khan, Hong You, Ji Dong Jia, Thomas Klein, Detlef Schuppan. New fibroblast activation protein inhibitor, CPD, attenuates fibrosis and chronic liver disease progresion in CCL4 induced liver fibrosis, but not in MDR2-/-mice. Journal of Hepatology, 2019; 70 (1), e20
10. Muhammad Ashfaq-Khan, Misbah Aslam, Muhammad Asif Qureshi, Marcel Senkowski, Shih Yen-Weng, Yong Ook Kim, Jörn M Schattenberg, Detlef Schuppan. A Common Dietary Component Wheat Amylase Trypsin Inhibitors as Drivers of Chronic Liver Disease in Pre-Clinical Models of NASH and Liver Fibrosis. Journal of Hepatology, 2019; 70, e518-e519
11. Leonhard Kaps, Lutz Nuhn, Niklas Choteschovsky, Adrian Klefenz, Misbah Aslam, Rudolf Zentel, Detlef Schuppan. Nanoparticular bisphosphonate to selectively target and repolarize liver macrophages for anti-fibrotic responses in experimental liver fibrosis. Wiley, 2019; 1127A-1127A
12. Leonard Kaps, Detlef Schuppan, Lutz Nuhn, Muhammad Ashfaq-Khan, Misbah Aslam, Adrian Klefenz, Niklas Choteschovsky. Nanoparticular bisphosphonate to selectively target and repolarize liver macrophages for efficient anti-tumour response. Elsevier, 2019; 366-E367
13. Aiting Yang, Wenshan Zhao, Hufeng Xu, Xu Fan, Misbah Aslam, Leonard Kaps, Yong Ook Kim, Jidong Jia, Detlef Schuppan, Hong You. Overexpression of Thymosin beta 4 By rAAV2/8 Suppresses Hepatic Fibrosis Progression and Accelerates Its Reversal Via Induction of Matrix Metalloproteinases. Hepatology, 2018; 68, 635A-636A
14. Misbah Aslam, Muhammad Ashfaq Khan, Muhammad Asif Qureshi, Sima Celik, Marcel Sacha Senkowski, Shih Yen Weng, Leonard Kaps, Yong Ook Kim, Detlef Schuppan. Rapamycin Promotes Tumoricidal Immunity in Murine HCC Via M1-Type Macrophage and Dendritic Cell Polarization and Enhancement of Cytotoxic T Cell. Hepatology, 2018; 68, 204A
15. Muhammad Ashfag Khan, Misbah Aslam, Marcel Sacha Senkowski, Muhammad Asif Qureshi, Shih Yen Weng, Yong Ook Kim, Jorn M Schattenberg, Detlef Schuppan. Dietary Wheat Amylase Trypsin Inhibitors Worsen Chronic Liver Disease in Pre-Clinical Models of Nash and Liver Fibrosis. Hepatology, 2018; 68, 1028A-1029A
16. Muhammad Ashfaq Khan, Misbah Aslam, Muhammad Asif Qureshi, Shih Yen Weng, Marcel Sacha Senkowski, Detlef Schuppan. Combined Treatment with Rapamycin and Zoledronic Acid Retards Growth of Advanced Murine Hepatocellular Carcinoma Via Activation of Innate and Adaptive Immunity. Hepatology, 2018; 68, 205A-206A
17. Misbah Aslam, Muhammad Ashfaq Khan, Muhammad Asif Qureshi, Marcel Sacha Senkowski, Mirko Nick, Leonard Kaps, Yong Ook Kim, Detlef Schuppan. Cumulative Antifibrotic Effect of Rapamycin and Zoledronic Acid in Murine Biliary Fibrosis. Hepatology, 2018; 68, 1139A-1140A
18. Ashfaq-Khan M, Aslam Misbah, Qureshi MA, Senkowski M, Weng SY, Schuppan, D. Rapamycin and Zoledronic acid strongly inhibit growth of advanced murine hepatocellular carcinoma via activation of innate and adaptive immunity. Journal of Hepatology, 2018; 68, S665-S666
19. Ashfaq-Khan M, Aslam M, Senkowski M, Weng SY, Schuppan D. Ablation of Interleukin-4 Receptor alpha in macrophages ameliorated steatohepatitis and fibrosis in murine model of non-alcoholic steatohepatitis (NASH). Journal of Hepatology, 2018; 68, S345-S346
20. Aslam M, Ashfaq-Khan M, Qureshi MA, Senkowski M, Weng SY, Schuppan D. Zoledronic acid suppresses tumour associated macrophages and myeloid derived suppressor cells in murine HCC. Journal of Hepatology, 2018; 68, S398
21. Aslam M, Ashfaq-Khan M,  Qureshi MA, Senkowski M, Weng SY, Schuppan D. Rapamycin and Zoledronic acid exert a potent antifibrotic effect in murine biliary fibrosis. Journal of hepatology, 2018; 68, S398
22. L Kaps, N Leber, A Yang, M Giardino, S Rizelli, M Aslam, A Mostafa, R Zentel, D Schuppan. M2 macrophage specfifc gene silencing in the liver using third generations mannose coated, siRNA-loaded nanohydrogel particles. Journal of hepatology, 2018; 68, S612
23. Aslam M, Pickert G, Ashfaq-Khan M, Schuppan, D.  Chemoprophylaxis of Azoxymethane/DSS-Induced Colonic Carcinogenesis in C57Bl/6 Mice using a Combination Therapy with Rapamycin and a Probiotic. Gastroenterology, 2018;154 (6), S-862
24. Friedrich Foerster, Carlotta Baumhoefner, Matthias Konhaeuser, Misbah Aslam, Jonathan Schupp, Andrea Tuettenberg, Peter Wich, Detlef Schuppan. Evaluation of dextran-based nanoparticles for hepatic macrophage repolarization in liver cancer. Hepatology, 2017; 66(1): 359A-359A
25. Ashfaq-Khan M, Aslam, M. Qureshi MA, Weng SY, Schuppan, D. “Combined treatment with Rapamycin and Zoledronic acid strongly inhibits growth of murine hepatocellular carcinoma via activation of the immune microenvironment”.  Hepatology, 2017; 66(1):422A-423A
26. Qureshi MA, Ashfaq-Khan M, Aslam, M. Hessel C, Senkowski M, Gasteiger D, Schuppan D. “Innate Lymphoid Cells Type 1 and 2 are Expanded in Early Stages of Hepatocellular Carcinoma in A Novel Murine Model Close to Human Hepatocarcinogenesis” Hepatology, 2017;66(1):412A-413A
27. Aslam, M. Ashfaq-Khan, M, Qureshi MA, Kaps, L. Weng SY, Senkowski M, Nick M, Kim YO, Heck R, Surabattula R, Schuppan D. “Zoledronic acid suppresses tumour associated macrophages and myeloid derived suppressor cells boosting immune modulating therapies against murine HCC”. Hepatology, 2017; 66(1):421A
28. Aslam, M. Ashfaq-Khan, M, Qureshi MA, Kaps, L. Weng SY, Senkowski M,  Nick M, Kim YO, Heck R, Surabattula R, Schuppan D. “Rapamycin and zoledronic acid synergistically repolarize tumour associated macrophages towards anti-HCC responses”.Journal of Hepatology, 2017; 66 (1), S465
29. MA Qureshi, M Ashfaq-Khan, M Aslam, MS Senkowski, YO Kim, T Zimmermann, D Schuppan. Characterization of the cancer immune microenvironment of Mdr2 (abcb4)-/-mice treated with diethylnitrosamine–a novel model close to human hepatocarcinogenesis. Journal of Hepatology, 2017; 66 (1), S465
30. Misbah Aslam, Muhammad Ashfaq-Khan, Leonard Kaps, Muhammad Asif Qureshi, Yong Ook Kim, Shih-Yen Weng, Friedrich Foerster, Rosario Heck, Rambabu Surabattula, Detlef Schuppan. Combined Treatment with Rapamycin and Zoledronic acid synergistically repolarize Tumour Associated Macrophages towards anti-HCC responses. Hepatology, 2016; 63 (1), 319A-320A
31. Ashfaq-khan, Muhammad, Misbah Aslam, Muhammad Asif Qureshi, Weng, Shih-Yen, Xiaoyu Wang, Zevallos, Victor, Kim, YO, Schuppan, Detlef. Nutritional Wheat amylase Trypsin Inhibitors, Activators of Toll like receptor 4, exacerbate non-alcoholic steatohepatitis in High fat fed mice, Hepatology, 2016; 63 (1), 792A-793A
32. Leonard Kaps, Nadine Leber, Misbah Aslam, Alexander Brose, Lutz Nuhn, Jonathan Schupp, Rudolf Zentel, Detlef Schuppan, Andrea Tüttenberg, Mustafa Diken. In vivo gene silencing in the liver: Comparison of siRNA-loaded non-biodegradable vs. biodegradable nanohydrogel particles for antifibrotic therapy. Hepatology, 2016; 63 (1), 115A
33.  Leonard Kaps, Lutz Nuhn, Misbah Aslam, Alexander Brose, Friedrich Foerster, Rudolf Zentel, Detlef Schuppan. In vivo Myofibroblast specific gene silencing in the liver using novel siRNA-loaded biodegradable nanohydrogel particles. Journal of Hepatology, 2016; 64 (2), S448
34. Ashfaq-khan, Muhammad, Misbah Aslam, Muhammad Asif Qureshi, Weng, Shih-Yen, Xiaoyu Wang, Zevallos, Victor, Kim, YO, Schuppan, Detlef. Nutritional Wheat amylase Trypsin Inhibitors, Activators of Toll like receptor 4, exacerbate non-alcoholic steatohepatitis in High fat fed mice. Hepatology, 2016; 63 (1), 792A-793A
35. Ashfaq-khan, Muhammad, Misbah Aslam, Weng, Shih-Yen, Zevallos, Victor, Kim, YO, Xiaoyu Wang, Schuppan, Detlef. Effect of Nutritional Wheat amylase Trypsin Inhibitors on the progression of non-alcoholic fatty liver disease. Journal of Hepatology, 2016; 64 (2), S680-S681

Research Grants and Contracts

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Other Research or Creative Accomplishments

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Selected Professional Presentations

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